1.ʻO nā waiwai kumu o HPMC
Helo hypomallose, inoa inoa Pelekane hydroxyprooppopalse, Anlia Hpmc. ʻO kānaʻano molecularʻo C8h15- (C10hl8o6) N-C8hlLel5 Hiki ke hanaʻia e nā alaʻelua Hoʻonohonohoʻia ka palapala i ka pūnaehana Anydroglucose o Cellulouse, a hiki i ke pae kūpono; ʻO ka mea'ē aʻe e mālama i ka linter linter a iʻole nā lāʻau lāʻau lāʻau, a me ka hana houʻana i ka momi a me nā pulupulu. ʻO HPMC kahiʻano mea kanu kūlohelohe maoli, a he mea aloha maikaʻi loa ia, he nui ka mea nui, he nui ka nui o nā kumu. I kēia manawa,ʻoi aku ka laulā ma ka home a ma waho, aʻo ia kekahi o nā mea hoihoi ma ka hoʻohanaʻana i nā lāʻau lapaʻau kiʻekiʻe.
Ke keʻokeʻo nei kēia huahana i ka waiū keʻokeʻo ma ke kala kalaʻole,ʻaʻole i ka momona a me ka momona, a aia i keʻano o ka nui o ke kahe. Ua paʻa loa ia ma lalo o ka hōʻikeʻana o ka mālamalama a me ka haʻahaʻa. ʻO ia ka mea i loko o ka wai anuanu e hana ai i kahi hopena collidal keʻokeʻo keʻokeʻo He mea nui loa ia ma 70% waiʻona a iʻole kaʻona a iʻole dimometl etone,ʻaʻole e hoʻokaʻawale i ka waiʻona, chlooryethane.
I ka wā o ka pH o ka hypromellose ma waena o 4.0 a me 8.0, he maikaʻi maikaʻi, a hiki iā ia ke noho ma waena o 3.0 a me 11.0. I ka wā o ka mahana he 20 ʻO ka mortiture e pili ana i ka comeporption coible o hpmc he 6.2%.
Ma muli o nā mea likeʻole o ka methoxy a me hydroxyproopsl i keʻano o ka hybormellosely likeʻole o nā huahana likeʻole. I nāʻike kiko'ī, nāʻano huahana likeʻole o nā huahana i loaʻa i nā hōʻailona lapaʻau kūikawā a me nāʻano likeʻole o ka termal, no laila e hoʻohanaʻia no nāʻano'ē aʻe. ʻO nā haumānaʻo Parmacopoteias o nā'āina likeʻole a me nā hōʻike e pili ana i nā hiʻohiʻona: e like me nā helu o nā huahana e like me nā helu likeʻole Ma ka United States Pharmacopoteiaia, ua hoʻohuiʻia ka inoa maʻamau i ka hopena e hōʻike ai i nā heluʻelua o ka manekopa.
2.ʻO keʻano o ka hoʻokuʻuʻana iā HPMC i ka wai
2.1ʻO keʻano wai wela
Mai ka hemoʻana o ka hyldpromellse i ka wai wela, hiki ke hoʻopauʻia i ka wai wela i ka hoʻomakaʻana, a laila hoʻoluʻu. Ua weheweheʻia nāʻano maʻamauʻelua e like me kēia:
(1) E kau i ka nui o ka wai i koiʻia i loko o ka ipu, a wela ia e pili ana i ka wai ma lalo o ka papa.
(2) Hoʻohui i ka 1/3 a iʻole 2/3 o ka wai i koiʻia a me ka wela o ka wai wela, a laila e hoʻohui i keʻano o ke kai me ka lohi.
2.2ʻO keʻano hui hui hui
Hoʻopili pihaʻia nā mea nui e ka hoʻopiliʻana me ka huiʻana me kahi mea likeʻole a iʻole ka nui o nā mea nui I kēia manawa, hiki ke hoʻopauʻia ka hypromellase me ka wāʻole.
3. Pono nā HPMC
3.1ʻO ka wai wai anuanu
Lulu i ka wai anuanu ma lalo o 40 ° C a iʻole 70% ethanol
3.2 ka mea hōʻino
ʻO ka hyphmellose ʻAʻohe o kāna hopena i ka ukuʻole a me ke kamaʻilioʻana me nā mea aloha a me keʻano o nā mea hoʻohui a me keʻano o nā mea hui a iʻole. No laila,ʻaʻole e hana hou nā mea hoihoi'ē aʻe me ia i ka wā o ke kaʻina hoʻomākaukau.
3.3 Huli
Ua paʻa loa ia i ka ACID lāuaʻo Alkali, a hiki ke mālamaʻia no ka manawa lōʻihi ma waena o PH 3 a me 1L me ka loliʻole ma keʻano he Viscosity. ʻO ka hopena kūpono o ka hypromellose (hpmc) he hopena anti-mildew a hiki ke mālama i ka hoʻomau maikaʻi ma mua o ka mālama lōʻihi. ʻO nā mea lapaʻau e hoʻohana ana i ka HPMC e like me ka nui o nāʻoliʻoli maikaʻi ma mua o ka hoʻohanaʻana i nā mea hoʻonaninani maikaʻi (e like me DXTRIN, ATC.).
3.4ʻO ka hoʻoponoponoʻana o Viscosity
Hiki ke hoʻohuiʻia nā kāleka Viscosity maʻamauʻo HPMC e like me nāʻano likeʻole, a ua kohoʻia konaʻano maʻi likeʻole, no laila ua kohoʻia ka hoʻopiliʻana e like me nā koi.
3.5 metaboli i loko
ʻAʻole i hoʻopiliʻiaʻo HPMC a iʻole metabilinized i ke kino,ʻaʻole e hāʻawi i ka wela, no laila he mea hoʻomaʻamaʻa palekana palekana palekana palekana.
3.6 palekana
Ua manaʻo pinepine ia ua loaʻaʻo HPMC i kahi meaʻoleʻole a me nā meaʻoleʻole. ʻO ka Dose Median Dose no nā moice he 5g / kg, a me ka median lethal dos no nā rats he 5.2g / kg. ʻAʻole maikaʻi nā hana o kēlā me kēia lā i nā kānaka.
4.ʻO ka noi o HPMC i hoʻomākaukau
4.1 e like me nā kiʻiʻoniʻoni kiʻiʻoniʻoni a me nā kiʻi kiʻi kiʻi kiʻi
Ke hoʻohana nei i ka hypromellose (hpmc) e like me ka papa hana papa hana i hoʻopaʻaʻia,ʻaʻole maikaʻi loa nā papaʻaina coated e like me ka momona Hoʻohanaʻia ka papa haʻahaʻa haʻahaʻa o kēia huahana ma muli o ka hoʻoheheʻe waiʻalani wai no nā papaʻaina a me nā pupu kiʻekiʻe, aʻo ke kiʻekiʻe kiʻekiʻe o ke kiʻi kiʻi kiʻiʻia no nā'ōnaehana Pricehic ʻO kaʻike ka mea maʻamau he 2.0% a 20%.
4.2 e like me ka pale a me ka mea hanaʻole
Hiki ke hoʻohanaʻia ka papa haʻahaʻa haʻahaʻa o kēia huahana e like me kahi mea paʻa a me ka meaʻole paha no nā papa, nā papa kiʻekiʻe, a me nā granuna Hoʻololi ka Dosage me nā hiʻohiʻona likeʻole a me nā koi. ʻO ka maʻamau,ʻo ka dosage o ka paleʻana no nā papaʻaina maloʻo he 5%, a me ka dosage o nā papa papa o nā papa papa he 2%.
4.3 Ma keʻano he mea hoʻokele
ʻO ka mea i hoʻopiʻiʻia he mea kūʻai akuʻo Gelcous Gel me ka hydrophilicity, hiki ke lohi i ka neʻeʻana o nā'āpana o nā'āpana Ke hoʻokūkū nei nā mea hoʻokele i kahi hana koʻikoʻi i ka hanaʻana i nā mea hoʻopiʻi. Heʻano maikaʻi loaʻo Hpmc i nā ahe o nā'ueke, a me kona hoʻohālikelikeʻana i ka hōʻemiʻana i ka hoʻopaʻapaʻaʻana o ka wīwī anuʻu. Hoʻohanaʻia ka papa kiʻekiʻe o kēia huahana o kēia huahana e like me ka hoʻomākaukauʻana o keʻano hoʻomehana i hoʻomākaukauʻia He hopena maikaʻi loa ia, maʻalahi ke maʻalahi i ka paleʻana i ka paia, a loaʻa i nā pā, a he mau'āpana'ōpala maikaʻi. ʻO ka Dosage maʻamau he 0.5% i 1.5%.
4.4 Ma keʻano he blocker, mālamaʻia i ka leka uila a me nā mea hoʻokele
Hoʻohanaʻia ka papa kiʻekiʻe o ka huahana o kēia huahana e hoʻomākaukau i nā papa hana hydropphilik, a i huiʻia ka hopena o nā mākeke. ʻO kāna hoʻohana hoʻohanaʻana he 10% ~ 80% (W / W). Hoʻohanaʻia nā helu haʻahaʻa haʻahaʻa e like me nā mea hana pore e like me ka hoʻokuʻuʻana i ka hoʻokuʻuʻana a iʻole nā hoʻomākaukauʻana i hoʻokuʻuʻia. ʻO ka hana mua e koiʻia no ka hopena o kēiaʻano o kēiaʻano o ka papaʻaina ke hiki ke hoʻokō wikiwiki, a mālamaʻia ka hopena o ke kinoʻana i ka maʻi lapaʻau i ke kino. Ke hālāwai neiʻo Hypromellose i ka wai,ʻo ia ka hydrates e hana i kahiʻano gel. ʻO keʻano o ka hōʻikeʻana o ka lāʻau lapaʻau mai ka papa matrix e pili nui ana i keʻano o ka'āpana o ka gel o ka gel i ke aniani.
4.5 pale pale i ka glue e like me ka thickener a me ka colloid
I ka manawa i hoʻohanaʻia ai kēia huahana e like me ka shaickener,ʻo ka hana maʻamau maʻamau he 0.45% ~ 1.0%. Hiki i kēia huahana ke hoʻonui i ka paʻa o ka nui o ka hydrophobic glue, e pale i keʻano pale, e pale i ka hoʻohālikelikeʻana, a me ka heʻeʻana he 0.5%
4.6ʻO nā mea capsule no nā capsules
ʻO ka maʻamau maʻamau ka capsule nā mea capsule copsule o ka copsule i hoʻokumuʻia ma Gelatin. ʻO ke kaʻina hana e ka pupu a Geletin Coplet, akā aia kekahi mau pilikia a me ka phenomena e pale aku i ka hoʻoheheʻeʻana a me ka neʻeʻana o ka maʻi maʻi maʻi. No laila,ʻo ka hyperamela, e like me keʻano o nā lāʻausaulia, ua hoʻomaikaʻiʻia i ka hale o Capsules, a ua hoʻomaikaʻi nuiʻia ma ka hale o Capsules, a ua hoʻomaikaʻi nuiʻia ma ka hale a mawaho.
4.7 e like me Biodahetive
ʻO kaʻenehana Biodohena,ʻo ka hoʻohanaʻana o nā mea hoihoi me nā polymers bioders, ma waena o ka hoʻomakaʻana o ka mucosa e hoʻokō ai i nā kumu o ka mucosa Ua hoʻohana nuiʻia ia i hoʻohanaʻia e hoʻomaʻamaʻaʻia e mālama i nā maʻi o ke kahe o ka nasal, waha a me nā'āpana'ē aʻe. ʻO Gastrointestinal Biodhesion Technology he mea kūʻai aku i ka'ōnaehana lawe kālā hou i kūkuluʻia i nā makahiki i hala. ʻAʻole wale nā mea e hoʻopiʻi ai i ka manawa noho o nā hoʻomākaukau haumāna ma ka hoʻolahaʻana o ka lāʻau lapaʻau i ka hoʻopiliʻana o ka lāʻau lapaʻau i ka.
4.8 e like me ke aloha nui
Me keʻano o ka hoʻohālikelikeʻana no kaʻili,ʻo Gel keʻano he hana kūpono e like me ka palekana, ka hoʻomaʻemaʻe maʻamau, a me nāʻano uku maʻamau. kuhikuhi.
Post Time: Feb-14-2025